Synthesis of lividomycin A 5''-phosphate, an enzymatically inactivated lividomycin A.
نویسندگان
چکیده
Sir: As described in the preceding paper1}, lividomycin A2) (I) is phosphorylated to its 5r/-phosphate by ATP and an enzyme prepared from Escherichia coli K-12 ML1410 R-81 carrying R factor and Pseudomonas aeruginosa TI-13. This structure of the phosphorylated and inactivated lividomycin A was proposed from chemical evidence and pmr data. In this communication, the synthesis of lividomycin A 5/r-phosphate is reported. The penta-N-benzyloxycarbonyllividomy-
منابع مشابه
Isolation and characterization of lividomycin A inactivated by Pseudomonas aeruginosa and Escherichia coli carrying R factor.
served in IR spectrum. The inactivated lividomycin A consumed 6.2 moles of periodate for 24 hours as does lividomycin A (5.9 moles). Methanolysis of the inactivated lividomycin A (refluxed in 0.4 N hydrogen chloride in methanol for 6 hours) gave 3'deoxyparomamine, methyl lividotriosaminide phosphate and a small amount of methyl lividobiosaminide phosphate. These results indicate that the inacti...
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The isolation of Providencia stuartii resistant to multiple aminoglycoside antibiotics prompted an investigation into the mechanism of their resistance. Crude enzyme extracts of a strain of P. stuartii inactivated kanamycin, lividomycin A, and butirosin B in the presence of adenosine 5'-triphosphate (ATP), as measured by a microbiological assay. The occurrence of inhibitory concentrations of 50...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 25 8 شماره
صفحات -
تاریخ انتشار 1972